Neurogenic Inflammation and Sensitivity to Environmental Chemicals
نویسندگان
چکیده
منابع مشابه
Neurogenic inflammation and sensitivity to environmental chemicals.
Neurogenic inflammation as a pathway distinct from antigen-driven, immune-mediated inflammation may play a pivotal role in understanding a broad class of environmental health problems resulting from chemical exposures. Recent progress in understanding the mediators, triggers, and regulation of neurogenic inflammation is reviewed. Evidence for and speculations about a role for neurogenic inflamm...
متن کاملNeurogenic inflammation and allergy
Neurogenic inflammation encompasses a series of vascular and non-vascular inflammatory responses, triggered by the activation of primary sensory neurons with a subsequent release of inflammatory neuromediators, resulting in a neurally mediated immune inflammation. Neuromediators are mainly released from neurons. Immune and/or structural cells are secondary sources of these mediators during immu...
متن کاملEpigenetics and environmental chemicals.
PURPOSE OF REVIEW Epigenetics investigates heritable changes in gene expression occurring without changes in DNA sequence. Several epigenetic mechanisms, including DNA methylation, histone modifications, and microRNA expression, can change genome function under exogenous influence. Here, we review current evidence indicating that epigenetic alterations mediate toxicity from environmental chemic...
متن کاملNeurogenic Inflammation: Additional Points
William Meggs's recent article, "Neuro-genic Inflammation and Sensitivity to Environmental chemicals" (EHP 101:234-238), provides a useful introduction to a rapidly growing area of knowledge in physiology and posits a number of interesting hypotheses regarding the health effects of airborne chemicals. Some specific technical points, however, merit comment. Meggs describes the common chemical se...
متن کاملNeurogenic mechanisms and salt sensitivity.
The concept of salt sensitivity is based on the observation that some individuals respond to a high salt intake with a marked increase in blood pressure, whereas others experience little or no blood pressure changes. Salt sensitivity is found much more frequently in hypertensive than in normotensive subjects,1 and its presence predicts a significantly greater increase of blood pressure with age...
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ژورنال
عنوان ژورنال: Environmental Health Perspectives
سال: 1993
ISSN: 0091-6765
DOI: 10.2307/3431548